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This manuscript describes the design and style, plans and prespecified analysis plan for the PARAMETER designThe PARAMETER become skilled at is a 52 week, Multicentre, Randomised, Double impaired, Active mastered, similar group study, connected with 51 centres from 13 countries (the uk 47%, south america 14%, Asia 19% and the USA 20% see online supplement for list of local investigators and engaging centres). The study is made up of screening period, A placebo run in and a preliminary double blind treatment period of 12weeks with LCZ696 monotherapy, followed by a double blind extension of 40weeks, during which add on therapy is allowed to reach the BP treatment goal. Patients will be randomised to get either once daily LCZ696 200mg or olmesartan 20mg for 4weeks, Followed by a forced titration to double the initial doses for 8weeks. immediately 12weeks, Patients with unchecked BP (Mean laying (microsoft) SBP >140 and/or msDBP >90mmHg) Will be prescribed amlodipine (2.5 5mg) immediately after which hydrochlorothiazide (6.25 25mg) as needed, At an time period of 4weeks up to week 24 cheap football jerseys (map 1). these studies has been approved by all relevant ethics committees.Study structure. HCTZ, Hydrochlorothiazide; msDBP, Mean sitting diastolic bp; msSBP, Mean sitting systolic low blood pressure.Open in new tabFigure1 Study shape.

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